The setting up of ACT-SA received a lot of interest in Southern Africa. In South Africa, Heather van Nierkerk, the former Executive Director of Amnesty International South Africa and Shirley Mabusela the former Commissioner of the South African Human Rights Commission took the leadership of registering the Trust in South Africa. Resultantly, it was registered under the Non-Profit Organisations Act (Reg Number 45.923 NPO refers). As time advanced, ACT-SA had champions in several SADC Member States:
- In Namibia, Mr. Norman Tjombe, the former Executive Director of the Legal Assistance Centre (LAC) joined ACT-SA as a member of the Regional Board of Trustees;
- As already said, in South Africa, there was Ms. Heather van Niekerk of Amnesty International South Africa and Ms. Shirley Mabusela of the South African Human Rights Commission. Ms. Shirley Mabusela served as the a member of the Regional Board of Trustees
- Apart from being one of the founders, Mr. Arnold Tsunga represented Zimbabwe in the Regional Board of Trustees. Mr Tsunga is the Africa Director of the International Commission of Jurists (ICJ) and before joining the ICJ, he was the Executive Director of the Zimbabwe Lawyers for Human Rights, and the Executive Secretary of the Zimbabwe Law Society. In 2006, he was awarded the Martin Ennals Award for Human Rights Defenders and also honoured as a Human Rights Defender in 2006 by Human Rights Watch. Mr. Tsunga is the outgoing Chairperson and is continuing as a board member of ACT-SA.
- In the Democratic Republic of Congo (DRC), Hon. Wildor Makonero who was a Senator of the Parliament of the DRC as well as member of the SADC-Parliamentary Forum was a representative of DRC in the Regional Board of Trustees
- In Tanzania, the late Prof Haroub Othmanserved as a member of the Regional Board of Trustees. The late Prof Othman, was a senior Lecturer at the University of Dar Es Salaam and the Presidentof the Zanzibar Legal Services Centre. After his untimely passing on, he was replaced by Prof. Chris Maina Peter who is a professor of law at the University of Dar es Salaam (UDSM).
- In Mozambique, ACT-SA was first represented by Hon.Paulo Comoane of LIGA before he was replaced by Albino Forquilha, the President of the National Association of Demobilised Soldiers of Mozambique;
- Chris Chisoni of the Episcopal Conference of Malawi represents Malawi;
- The late Prof. Alfred Chanda was the representative for Zambia before he was replaced by Mr. Reuben Lifuka.
- The Lesotho representative is Booi Mohapi, the Executive Secretary of the Catholic Commission for Justice and Peace.